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Jan 3, - For adults, most brown recluse spider bites can be treated at home with good results. But about 10% of them cause ulcers or blisters that damage your skin so badly that you need a doctor's care. If your symptoms are mild, try these simple home remedies: Clean it with soap and water. After being bitten by a brown recluse spider, you may have red skin and a blister where you were bitten. You may also have intense pain and itching around the.